A new path involving nanoparticles integrating a polyphenol with antioxidant properties found in green tea, neurotransmitter, and amino acid has the potential to treat Alzheimer’s Disease (AD) by changing the path of the progression of the disease, slowing it, improving memory, and supporting thinking skills.
Alzheimer’s disease is a growing global health concern. As the population ages, the disease poses significant challenges in terms of patient care, economic burden underlining the need for effective treatments and preventive strategies.
Conventional Alzheimer’s therapies often target only a single pathological feature such as amyloid aggregation or oxidative stress, yielding limited clinical benefit. However, AD which is a multifactorial disease and hence needed a multifunctional nanoplatform capable of addressing multiple disease mechanisms simultaneously.
Researchers at Institute of Nano Science and Technology (INST), Mohali, an autonomous institute of the Department of Science and Technology (DST), integrated nanotechnology, molecular biology, and computational modelling to develop a multifunctional therapy for Alzheimer’s Disease.
The therapy integrates epigallocatechin-3-gallate (EGCG) an antioxidant found in green tea, dopamine, a neurotransmitter important for mood and tryptophan, an amino acid involved in many cellular functions into a nanoparticle called EGCG-dopamine-tryptophan nanoparticles (EDTNPs). This enables it to simultaneously targets amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration, four key pathological hallmarks of AD.
